Center for the Epigenetics of Common Human Disease (CEGS)
This project aims to develop tools for understanding the epigenetic basis of common human disease, with emphasis on DNA methylation. The tools will be developed for carrying out large-scale epigenetic measurements both technically and statistically, determining in the process parameters to measure in large patient cohorts, epigenetic variation across individuals, families, time, and tissue types. The tools will be applied in the context of the new field of epigenetic epidemiology. The latter component of the project will apply a novel approach, Genome-Wide Integrated Susceptibility (GWIS) that combines genome-wide methylation analysis with existing Genome-Wide Association Studies (GWAS) and epidemiologic phenotype data, to three model populations: bipolar disorder, aging, and autism.