Return to list Michela Fagiolini, PhD
Michela Fagiolini, PhD
Assistant Professor of Neurology, Harvard Medical School
Research Associate in Neurology, Boston Children’s Hospital
Boston Children's Hospital
F.M. Kirby Neurobiology Center
Center for Life Science, Room 13-034
3 Blackfan Circle
Boston, MA 2115
Neurons acquire multiple functional properties through experience-dependent development during specific times in early postnatal life called “critical periods”. In recent years they have achieved the first direct control over critical period timing by manipulating a specific subset of local inhibitory circuits in the visual cortex. Dr. Fagiolini's research focuses on the mechanisms underlying these fundamental processes and how they may be altered in neurodevelopmental disorders. To this end, they combine molecular techniques with electrophysiological and behavioral analysis of systems level phenomena in vivo.
Currently Dr. Fagiolini's lab is studying experience-dependent brain development in mouse models of autism spectrum disorders (ASDs). They are particularly focused on Rett syndrome, a leading cause of intellectual disability with autistic features. The lab is developing new strategies to restore cortical function and critical period timing by targeting Excitatory/Inhibitory circuits as a possible therapeutic intervention.
Visual Circuit Regression and its Rescue in RTT Models - R01 NS095959-01A1