Return to list Jonathan Lipton, MD, PhD

Investigator

Jonathan Lipton, MD, PhD

Title
Instructor in Neurology, Harvard Medical School
Department

Neurology

Address

Boston Children's Hospital
300 Longwood Avenue
Boston, MA 02115

Phone

617-735-3260

Email

Jonathan.Lipton@childrens.harvard.edu

Biography

 As a child neurologist and sleep physician, I am particularly aware of the importance of sleep for children with neurological disease. Sleep and circadian rhythm dysfunction are extremely common in neurodevelopmental disorders and have been suggested as risk factors for autism, bipolar disorder and depression, and several forms of cancer. Motivated by my clinical experience, my research seeks to understand the biological relationships between the circadian clock and diseases of the developing brain.

I have recently joined the faculty of the F.M. Kirby Center for Neurobiology in the Department of Neurology at Boston Children’s Hospital and Harvard Medical School as a Principal Investigator. The overarching goal of my laboratory is the identification of targetable mechanisms that focus on the link between biological timing and brain disorders. We have three inter-related goals: (1) To determine the role of BMAL1 and the circadian clock in synaptic function and behavior. (2) To establish the biochemical and molecular mechanisms of BMAL1 and clock-mediated translation. (3) Determination of the molecular and developmental logic of the clock-dependent circadian translatome.

 

Research
The Circadian Clock as a Capacitor for TSC-related Phenotypes - Tuberous Sclerosis Alliance