IDDRC Site Map

IDDRC Information Pages

• Administrative Core
• Basic Neuroscience
• Become an IDDRC Investigator
• Cell Sorter Core
• Cellular Neuroscience Core
• Children’s Hospital Boston Intellectual and Developmental Disabilities Research Center (IDDRC)
• Clinical/Translational Neuroscience
• Contact the Children’s Hospital Boston IDDRC
• Genetics
• History of the IDDRC
• IDDRC Cores
• IDDRC Seminars
• IDDRC Series & Events
• Imaging Core
• Links
• Major Scientific Accomplishments
• Molecular Genetics Core
• Neurology Grand Rounds
• Our Investigators
• Our Research
• Proteomics Core
• Research List
• Transgenic Core
• Upcoming IDDRC Seminars & Events
• Welcome to the Children’s Hospital Boston IDDRC
• Why Become a IDDRC Investigator

IDDRC Investigators

• Heidelise Als, PhD
• Matthew P. Anderson, MD, PhD
• Alan Beggs, PhD
• David Bellinger, PhD
• Larry Benowitz, PhD
• David Breault, MD, PhD
• Constance Cepko, PhD
• Chinfei Chen, MD, PhD
• David Clapham, MD, PhD
• David P. Corey, PhD
• Gabriel Corfas, PhD
• Sandeep Robert Datta, MD, PhD
• Michael Tri Hoang Do, PhD
• Susan Dymecki, MD, PhD
• Elizabeth Engle, MD
• Mel B. Feany, MD, PhD
• John Flanagan, PhD
• Anne Fulton, MD
• Nadine Gaab, PhD
• Albert Galaburda, MD
• Eugene Goldfield, PhD
• Lisa Goodrich, PhD
• Patricia Ellen Grant, M.D.
• Michael Greenberg, PhD
• Chenghua, Gu PhD
• Emanuela Gussoni, PhD
• Xi He, PhD
• Zhigang He, PhD
• Takao Hensch, PhD
• Joel Hirschhorn, PhD
• Anthony Hollenberg, MD
• Jeffrey R. Holt, PhD
• Laurie Jackson-Grusby, PhD
• Judith Jebanathirajah Steen, PhD
• Ursula B. Kaiser, MD
• Peter Kang, MD
• Walter E. Kaufmann, MD
• William Kiernan, PhD
• Hannah Kinney, MD
• Michael Klagsbrun , PhD
• Isaac Kohane, MD, PhD
• Jordan Kreidberg, MD, PhD
• Gabriel, Kreiman PhD.
• Louis Kunkel, PhD
• David Kwiatkowski, MD, PhD
• Maria Lehtinen, PhD
• X. Sean, Li PhD
• Stephen D. Liberles, PhD
• Qiufu Ma, PhD
• Richard Maas, MD, PhD
• Rebekah Mannix, MD, MPH
• Charles Nelson, PhD
• Jane Newburger, MD
• Leo Otterbein, PhD
• Xianhua Piao, MD, PhD
• Scott L. Pomeroy, MD, PhD
• Vijaya Ramesh, PhD
• Michael J. Rivkin, MD
• Paul A. Rosenberg, MD, PhD
• Bernardo Sabatini, MD, PhD
• Mustafa Sahin, MD, PhD
• Thomas Schwarz, PhD
• Rosalind Segal, MD, PhD
• Yang Shi, PhD
• Lois Smith, MD, PhD
• Janet Soul, MD
• Beth Stevens, PhD
• Clifford Tabin, Ph.D.
• Deborah Waber, PhD
• Christopher Walsh, MD, PhD
• Simon Warfield, PhD
• Morris White, PhD
• Clifford Woolf MB, BCh, PhD
• Bruce Yankner, MD, PhD
• Junying Yuan, Ph.D.

IDDRC Accomplishments

• Mechanisms that Restrict Axon Regeneration after Injury
• A Signal Transduction Pathway that Promotes Neuronal Survival
• Neural Progenitors, Cellular Transplantation and Gene Therapy
• The Development of Phospho-specific Antibodies as Key Reagents for Identifying Signal Transduction Pathways in the Brain
• A Genetic Program Regulated by Neuronal Activity
• The Use of Human Genetics to Identify Genes that Regulate Human Brain Development and Cognition
• Wnts Signal Transduction and Nervous System Development
• The Developmental Biology of Neural Tube Formation
• The Modulation of Neuronal Excitotoxicity by Astrocytes
• Genetic Imprinting in Human Genetics
• Molecular Approaches to Down's Syndrome and Alzheimer’s Disease
• Congenital Heart Disease, Cardiac Surgery and Brain Development
• Genomic Analysis of Brain Tumors
• Duchenne/Becker Muscular Dystrophy
• Clinical, Cellular and Molecular Aspects of Brain Injury in the Premature Infant
• Adverse Effects of Low Lead Level Exposure
• Adverse Effect of Maternal Phenylketonuria on Offspring
• Adverse Effect of Cranial Radiation on Cognition
• "Genetic Engineering" and Gene Therapy
• Visual Function in Children
• Deprivation Amblyopia and the "Critical Period"
• Behavior and Genetics
• Animal Models of Neurological Disease and of Cerebral Malformations
• Neuroepidemiology and Neuropathology of Periventricular White Matter Injury of the Premature Newborn
• Infantile Hydrocephalus and CSF Dynamics
• Retrograde Transport by Nerve Cells
• Manipulation of Human Chromosomes by Dyes and Cell Sorting
• Neuronal Migration During Brain Development

IDDRC Research

• Bioinformatics Software for MRI of Brain Development
• Gene Expression in and Therapeutic Application of Muscle Stem Cells
• Outcomes in Adolescence after Repair of D-TGA RO1 HL77681
• Understanding the Cognitive Impact of Early life Epilepsy
• 30 Year Followup of Mental Health Outcome Following Childhood Malnutrition
• A Conditional RNAi Approach to Find Genes Required for Hearing in Mice
• Active Bottle For Home Care of Dysphagic Infants: Phase II
• Adrenal Regeneration: Stem Cells and Lineage Development
• Alexander Disease: Cellular and Molecular Mechanisms
• Alpha Actinins in Normal and Diseased Muscle
• Altered Sensibility Following Peripheral Nerve Damage
• Analysis and Therapy of Muscular Dystrophy in Zebrafish
• Analysis of neurodevelopment using mouse mutagenesis
• Anatomic Variations in Muscle Gene Expression
• Angiogenesis and Chronic Rejection
• Assessing the Role of Nogo Receptor and its Ligands in Axon Regeneration
• Autism Centers of Excellence
• Biomarker Discovery in Muscles from FSHD Patients
• BMP and FGF Signaling in Kidney Progenitor Cells
• Brain Structure and Function in Adolescents after the Fontan Operation
• Brainstem Maturation in the Sudden Infant Death Syndrome
• Candidate Gene Studies of Obesity Guided by Whole Genome Association Data
• Canonical Transient Receptor Potential (TRPC) Subfamily Function in Hippocampus
• Carbon Monoxide as a Therapy for Septic Shock
• CatSpers: sperm-specific ion channels; targets for male contraceptives
• Cell identity determination in cerebral cortex
• Cell-cell Interactions in Cerebellar Development
• Cell-Cell Signaling in Visual Development
• Cellular and Molecular Mechanisms of Inner Ear Morphogenesis
• Cellular Basis of Periventricular Leukomalacia in Autopsied Human Brain
• Cellular Responses to Hypoxia
• Center for Epigenetics of Common Human Disease (CEGS)
• Center for the Epigenetics of Common Human Disease (CEGS)
• Cerebrospinal Fluid Proteome Mediated Signaling in the Developing CNS
• Characterization of Neuropilin, A Novel VEGF Receptor
• Characterization of Telomerase-Expressing Intestinal Stem Cells
• Characterizing Odor Maps in the Olfactory Bulb and Cortex
• Circadian Clock of the Paraventricular Nucleus
• Circadian Clock Regulation of the Mammalian Retina
• Circuit-based therapy for Rett Syndrome
• Comparative Synaptic Pathobiology of Tuberous Sclerosis and Fragile X Syndrome
• Connexins and Electrical Synapses in the Retina and Brain
• Continuous Monitoring for Cerebral Pressure-Passivity in Premature Infants
• Corepressor Regulation of Nuclear Receptor Action
• Cortico-Spinal Repopulation from Precursors for Repair
• CST Regeneration and Functional Recovery
• Dendritic Ca2+ Signals in Striatal Medium Spiny Neurons
• Determination of Retinal Cell Fate
• Development of a Behavioral Outcome Measure for Rett Syndrome (IRSF #2804)
• Developmental Disabilities Core Grant: University Center of Excellence in Disabilities
• Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits
• Developmental Regulation by miRNAs
• Dietary Control of Angiogenesis in Retinopathy Model: Basis for Clinical Trials
• Discovering Human Birth Defect Genes from Chromosomal Rearrangements
• Dissecting Non-coding RNA Function in Critical Period Brain Development/ Disorder
• DNA Damage and Neurodegeneration in the Aging Brain
• Does Early Experience Improve Preterm Neurodevelopment?
• Does Early Experience Improve Preterm Neurodevelopment?
• Early Visual Signals and Neural Development
• Effects of General vs Regional Anesthesia on Infant Neurodevelopment and Apnea
• Electrical Stimulation of Immediate Early Genes
• Elucidation and Rescue of Amygdala Abnormalities in the Fmr1 Mutant Mouse Model of Fragile X Syndrome
• Engogenous Gas Molecules as Transcription Factors
• Environment, the Perinatal Epigenome, and Risk for Autism and Related Disorders
• Environment, the Perinatal Epigenome, and Risk for Autism and Related Disorders
• Epigenetic Regulation of Medulloblastoma
• Epigenetic Regulation of Puberty
• Epileptogenic Effects of Perinatal Hypoxia
• Epithelial Signaling of Mammalian Facial Topology
• Excitotoxic Injury to Developing Oligodendrocytes
• Finding autism genes by genomic copy number analysis
• From structure to function in the study of Autism Spectrum Disorders
• Function and Regulation of Intercellular Communication
• Functional Analysis of the Cardiac Transcription Factor Nkx2.5
• Gene Regulation and DNA Damage in the Aging Brain
• Genes Essential to Motor Axon Guidance in Drosophilia
• Genes that deregulate in TOR Signaling as candidates for autism spectrum disorders
• Genetic Analysis of Axonal Transport in Synaptogenesis
• Genetic Dissection of Auditory Circuit Assembly
• Genetic Etiologies of Horizontal Strabismus
• Genetic Factors that Regulate the Onset of Puberty
• Genetic Studies of Interstitial Cystitis
• Genetics of New Synaptic Components and Their Functions
• Genomic Analysis of Human Aging and Cognitive Decline
• Genomic Analysis of Medulloblastomas
• Genomic Imprinting and Embryonic Development
• GPing: Informatics for Personal Control of Genomic Data
• Hedgehog Signaling and Organogenesis of the Limb
• Human Epilepsy Genetics: Neuronal Migration Disorders
• Identification and Function of Receptors and Ligands
• In Vivo Functions of Myotubularins and Therapy for Myotubular Myopathy
• Inducible Expression of Exogenous Potassium Channels in Hair Cells
• Induction of Neurogenesis in Neocortex for Brain Repair
• Informatics Algorithms for Neural Circuitry Ultrastructure
• Informatics for Integrating Biology and the Bedside(RMI)
• Innate Immunity in the Pathogenesis of PVL
• Integrins in Epithelial Morphogenesis
• Investigating the Role of Glia in Activity-Dependent Synapse Elimination
• Ion Channel Function in Auditory & Vestibular Hair Cells
• IRS-2 Function in Beta Cell Physiology