We propose to perform structural and functional MRI (fMRI) in 155 patients at ages 13-17 years, compared with three other groups: 55 normal adolescents, and previously –collected d-TGA and TOF adolescents. Aims of this project are: 1) evaluate whether Fontan adolescents have more abnormalities of brain structure and microstructure than normal adolescents or those with d-TGA and TOF; 2) evaluate whether Fontan adolescents have worse executive and visual-spatial function on fMRI than normal adolescents or those with d-TGA and TOF; 3) explore the relationship of MRI measures to medical and genetic factors; and 4) explore whether MRI abnormalities are associated with worse neurodevelopmental outcomes in Fontan adolescents.
